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AbbVie Expands Psychiatric Drug Prospects, Inking R&D Pact With Neuroscience Startup

MedCity News

The companies aim to bring patients drugs that offer the benefit of psychedelics but with a better side effect profile. The post AbbVie Expands Psychiatric Drug Prospects, Inking R&D Pact With Neuroscience Startup appeared first on MedCity News.

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FDA drug dosage optimisation guidelines signal clinical trial reform

Pharmaceutical Technology

The demand came amid concerns that the drug causes a slew of side effects such as nausea, diarrhea, and liver issues. If the new clinical study finds that a lower drug dose can achieve similar efficacy, the hope is that this could result in fewer side effects for patients.

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GSK shelves arthritis blockbuster hope otilimab after lacklustre data

pharmaphorum

There has been somewhat better news for GSK for another of its top pipeline prospects – renal anaemia drug daprodustat – although that also came with disappointment. GSK licensed otilimab from German biotech MorphoSys in 2013 in a deal valued at up to €423 million, including around €23 million upfront. Daprodustat backed.

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Biogen and Eisai’s Alzheimer’s drug secures support in closely watched AdCom

Pharmaceutical Technology

A US Food and Drug Administration (FDA) Advisory Committee (AdCom) has unanimously voted in support of Eisai and Biogen’s Leqembi and its clinical benefit in patients with early Alzheimer’s disease , raising the drug’s full approval prospects.

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FDA slaps partial hold on Biogen, InnoCare MS drug

pharmaphorum

While the partial hold may simply be a hiccup for InnoCare and Biogen’s programme, it does undermine prospects for orelabrutinib, which is one of several oral BTK inhibitors being developed for MS and other autoimmune diseases. Antibodies like Ocrevus also struggle to penetrate the CNS and hit MS at the site of the problem.

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Expanding ketamine’s horizons to treat rare neurological disorders

Pharmaceutical Technology

There is not a whole lot of evidence to say these effects are underlying ketamine’s therapeutic action in humans, says Kohtala. A different promising prospect for ketamine’s use is in status epilepticus, says Dr. Manan Shah, assistant professor in Neurocritical Care at Augusta University’s Department of Neurology and Neurosurgery, Georgia.

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Valneva’s Lyme disease vaccine faces final clinical test in a sparse landscape

Pharmaceutical Technology

On August 8, Pfizer and Valneva announced the initiation of a Phase III study with their Lyme disease vaccine , bringing the prospect of an injection to prevent the condition disease one step closer to reality. The biggest challenge for the vaccine is in its acceptance by the general public.

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