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Side Effects are Limiting GLP-1 Drug Efficacy: How Can Personalization Offer a Solution?

MedCity News

By integrating digitization and machine learning, there is an opportunity to deliver personalized care to all patients and scale precision dosing with minimal physician involvement, maximizing the effectiveness and accessibility of these drugs. appeared first on MedCity News.

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Preventative approach could reduce immunotherapy side effects

European Pharmaceutical Review

New research from the US indicates that a prophylactic treatment before immunotherapy can significantly reduce the rate of cytokine release syndrome (CRS) in multiple myeloma patients. Immunotherapy drugs like teclistamab can result in potentially fatal side effects, including CRS and immune cell-associated neurotoxicity syndrome (ICANS).

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Metformin helps manage weight gain side effect of SGAs

European Pharmaceutical Review

SGAs used to treat bipolar disorder are often effective at helping young patients’ mental health improve but can have significant side effects including elevated blood pressure and glucose, increased appetite, as well as weight gain. Metformin is typically used for Type II diabetes treatment.

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Study finds no link between Novo Nordisk’s GLP-1 drugs and suicidal ideation

Fierce Pharma

In fact, the research shows that those who were on semaglutide were less likely to have suicidal thoughts than patients on other diabetes and obesity meds.

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UK agency pilots biobank to study links between genetics and drug side effects

Pharmaceutical Technology

The Medicines and Healthcare products Regulatory Agency (MHRA) aims to launch a pilot genetic biobank that will gather patient data to associate drug-related adverse events to their genetic makeup. Side effects due to drugs are responsible for one in every 16 hospital admissions in the UK, based on the announcement.

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Serious Side Effect Sidelines Gene-Edited Sickle Cell Therapy from Graphite Bio

MedCity News

Graphite Bio voluntarily paused a Phase 1/2 test of its gene-edited therapy for sickle cell disease after the first patient in the study developed a serious blood complication. The setback will also delay plans to reach the clinic with another genetic medicine in its pipeline.

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Aiming for ‘Magic Bullets’ in Medicine: Are We Shooting Ourselves in the Foot?

Clarivate

A ‘magic bullet’ medicine that can cure a disease quickly and completely, [1] without deleterious side effects. [2] In 1897, Ehrlich proposed that certain cells expose a set of side chains on their surface, later termed ‘receptors’, which are associated with specific recognition. [3]