Sat.Oct 15, 2022 - Fri.Oct 21, 2022

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How to evolve artificial intelligence models alongside societal needs

MedCity News

As society becomes more open to and reliant on these tools, it is the responsibility of technology companies, especially those tasked with assisting people’s mental health, to build and maintain artificial intelligence and machine learning models that adapt alongside societal needs.

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Tackling immune-mediated disease with CAR Tregs

European Pharmaceutical Review

In recent years there has been significant development within the cell therapy field, as chimeric antigen receptor (CAR) T-cell therapy demonstrated an ability to transform the treatment of patients with haematological malignancies. Recognising the potential of CAR T cells to act as highly targeted therapeutics, several biotechnology companies – including Sangamo Therapeutics – have established development pipelines of CAR T regulatory cells (Tregs) that aim to tackle immune?

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Lilly agrees to acquire gene therapy developer Akouos for $610m

Pharmaceutical Technology

Eli Lilly and Company has signed a definitive agreement for the acquisition of all outstanding shares of precision genetic medicine firm Akouos for a total deal value of up to nearly $610m or up to $15.50 for each share in cash. The deal comprises an acquisition value of $12.50 for each share in cash payable at closing along with one non-tradeable contingent value right per share (CVR) of up to another $3 in cash.

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Frontiers Health 2022 – day 2

pharmaphorum

And the LIVE coverage continues as we head into Day Two… This day is set to hold even more points of interest, with the demonstration ‘CX innovation: building experiences that work for customers’ (moderated by Healthware Group’s global head of digital strategy and customer engagement Yannick Valenti), as well as the masterclass ‘How to maximise learning science to affect behaviour change’ with Meducate Global’s president, Lawrence Sherman, and MD of Healthware MedComms & SWM, Francis M

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AI Strategies for Sales Managers: How to Cut Down on Tedious Admin Work

What if you could help your sellers stop wasting 72% of their day on non-selling activities and focus on bringing in revenue? Incorporating AI in your enablement workflows can help you cut down on busy work, get projects done faster, and let your team (and you!) focus on making a bigger impact. We put together this guide to show you how to use AI to cut time and costs for projects, including collateral creation, development of training videos, and automating tedious processes.

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Cancer drug biotech Enliven shifts to reverse to move forward as a public company

MedCity News

Enliven Therapeutics’ reverse merger with Imara will form a combined company with $300 million to finance clinical development of new cancer drugs. Its most advanced program is a tyrosine kinase inhibitor for chronic myeloid leukemia.

Biopharma 127
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CHMP recommends Pluvicto® for treating advanced prostate cancer

European Pharmaceutical Review

Novartis announced that The European Medicines Agency’s (EMA’s) Committee for Medicinal Products for Human Use (CHMP) has recommended granting a marketing authorisation for Pluvicto ® radioligand therapy for treatment of patients with prostate cancer. Pluvicto combines a targeting compound (ligand, in this case directed to PSMA) with a therapeutic radioisotope (in this case lutetium-177).

Medicine 124

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Alzheimer’s Diagnostic Test Spots Amyloid ? Exosomes in Blood

Medgadget

Researchers at Hokkaido University in Japan have developed a biomarker test for Alzheimer’s disease that detects amyloid ? binding exosomes in a blood sample. While amyloid ? plaques in the brain are characteristic of Alzheimer’s, these researchers have previously reported that amyloid ? build-up in the brain is associated with an increase in amyloid ?

Patients 106
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Eyenuk raises $26M for diabetic retinopathy screening tech

MedCity News

Eyenuk, a company that makes technology for eye screenings, raised $26 million in a Series A funding round, bringing its total funding to more than $43 million. Research shows that the company’s AI system is more accurate in detecting diabetic retinopathy than a clinical examination from a general ophthalmologist or a retina specialist.

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EC approves CAR T-Cell therapy for B-cell lymphoma

European Pharmaceutical Review

Kite announced that the European Commission (EC) has approved the use of cell therapy Yescarta ® for treatment of patients with diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL), who relapse within 12 months or are refractory to, first-line chemoimmunotherapy. The approval is based on results from the Phase III ZUMA-7 study, the largest and longest trial of a CAR T-cell therapy versus standard of care (SOC) in this patient population.

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Novel CSF biomarkers signal new avenues for Parkinson’s therapeutics

Pharmaceutical Technology

A new study identifies a novel cerebrospinal fluid biomarker for Parkinson’s disease, expanding the scope of possible drug targets. Last week, Nature magazine published a paper detailing an in-situ study of Parkinson’s disease (PD), showing protein structural changes in cerebrospinal fluid (CSF) between healthy individuals and Parkinson’s patients. There is potential that these structural changes could allow for a new method of differentiating different disease subtypes, thus expanding the scope

Patients 105
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Bayer extends elinzanetant trials to include breast cancer

pharmaphorum

Bayer has added another clinical trial to its extensive phase 3 programme for oral neurokinin antagonist elinzanetant, hoping to show that it can treat vasomotor symptoms (VMS) in breast cancer patients. Elinzanetant is already being tested in the OASIS trials for VMS associated with menopause – an indication in which Bayer is in a head-to-head race with Astellas and its fezolinetant drug candidate – and breast cancer could represent a sizeable additional patient population for the drug.

Patients 108
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How to improve data literacy within healthcare organizations

MedCity News

Healthcare organizations must ensure they have a data-literate workforce that is confident in using the data and is empowered in using it to make decisions. Here are some best practices that hospitals can implement to better empower their employees to make data-driven decisions.

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Immunotherapy shows benefits for hospitalised COVID-19 patients

European Pharmaceutical Review

Apogenix , a biopharmaceutical company developing next generation immunotherapeutics, announced that asunercept showed statistically significant benefits for hospitalised COVID-19 patients in the ASUNCTIS trial. Apogenix’s lead immunotherapy candidate, asunercept is a fully human fusion protein, consisting of the CD95 receptor and an IgG1 antibody. It is being developed for the treatment of solid tumours, haematological malignancies and viral infections such as COVID-19.

Patients 105
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Fluorescence Imaging System Illuminates Tumor Depth

Medgadget

Medical researchers at Washington University School of Medicine in St. Louis have developed a fluorescence imaging technique that allows them to illuminate a tumor in situ and calculate its depth below the surface of the body. The technique could assist surgeons in accurately removing a tumor and successfully excising an appropriate margin of healthy tissue to reduce the chances of tumor recurrence.

Medicine 105
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Optimizing Clinical Supply Strategy: Navigating Challenges & Finding Your Ideal Model

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Frontiers Health 2022 – day 1

pharmaphorum

Frontiers Health 2022 in Milan is LIVE! Opening Day One will be Healthware Group’s CEO and founder Roberto Ascione and WTF Health’s founder and host Jessica DaMassa. The day’s keynote addresses will include ‘The H is for humanity’ by MD of Taliossa Tony Estrella and founder and trustee of Rachel’s House Lynna Chandra, as well as ‘Creative disruption in delivering novel VR solutions in pain: evidence, teamwork, and delivery’ by Christopher Eccleston, professor of medical psychology at the U

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Here’s 40 years of cardiac advancements that few know about

MedCity News

With so much supporting data and real-world success, it is time for catheter ablation to become a routine treatment option for patients suffering from arrhythmias.

Patients 133
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Make confident operational decisions by understanding your microflora

European Pharmaceutical Review

The newest revision to regulatory guidance Annex 1 illustrates more stringent contamination control requirements; it is now a regulatory expectation for manufacturers to implement comprehensive and reliable contamination control strategies. Environmental monitoring (EM) programmes can help keep you compliant, measuring the state of control of production and ensuring product safety.

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Screening App to Diagnose Parkinson’s, COVID-19 from Voice

Medgadget

Researchers at RMIT University in Melbourne, Australia, have developed an app that is intended to provide early diagnosis for Parkinson’s disease and severe COVID-19. The artificial intelligence-powered technology works by analyzing voice recordings, having previously been trained to recognize the vocal hallmarks of these diseases by listening to recordings of patients.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Text message therapy for depression works in young adults

pharmaphorum

Young adults with depression have been treated effectively with a cognitive behavioural therapy (CBT) course – delivered via text message – in a pilot study conducted by researchers in the US. The trial looked at a four-week CBT course adapted from a face-to-face programme to work via text messages, followed by a four-week follow-up period, in around 100 young adults in the US with at least one symptom of moderate depression and no recent history of antidepressant therapy.

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Report: Insurers from 55 countries expect healthcare benefit costs to jump 10% in 2023

MedCity News

The 10% increase is the largest in almost 15 years, the Willis Towers Watson survey found. Most of the insurers, or 75%, blamed the overuse of care for the rise in medical costs.

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European Pharmaceutical Review Issue 5 2022

European Pharmaceutical Review

Included in this issue: PATENTS. Patents: a necessary evil? David Elder, David P Elder Consultancy. MICROBIOLOGY. Pharma’s green mission: trends in bacterial endotoxin testing. Hannah Balfour. Lindsey Silva, Carmen Marín Delgado de Robles, Viviane Grunert da Fonseca and Evelyn Der, Roche Group. QA/QC. An Annex 1 and Pharma 4.0 perspective on water quality.

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He helped discover BMS’s psoriasis pill Sotyktu. Here’s what he has to say about early science in Big Pharma

PharmaVoice

Bristol Myers Squibb’s senior principal scientist Ryan Moslin shares why his team was built for success and how they ushered a potential psoriasis blockbuster through discovery.

Pharma 98
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How to Prove Marketing Value: Demonstrate Content ROI and Contribution to Sales

Every marketer knows how important it is to prove their efforts drive sales opportunities, but that’s easier said than done. When problems like sales and marketing misalignment, lack of data, and wasted efforts persist, marketers can’t measure, prove, or increase their impact on revenue at a time when demonstrating marketing value is critical. Using analyst and expert data, this guide to marketing impact and content attribution explains: How B2B buyers use content The most common types of conten

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Bringing the promise of immunotherapy to a broader population

pharmaphorum

When James P Allison and Tasuku Honjo were awarded the Nobel Prize for Medicine in 2018 for their discovery of cancer therapy through inhibition of negative immune regulation, it shone a light on decades of research into recruiting the immune system to fight cancer. Their success led to the discovery of an entirely new principle for cancer therapy – the field of immuno-oncology – one that is now a mainstay of cancer treatment, changing the way these diseases can be managed.

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Report: What drives consumers to MA plans and others to traditional Medicare

MedCity News

Many Medicare Advantage enrollees choose their plans because they offer more benefits than traditional Medicare and have limits on out-of-pocket costs. Traditional Medicare plans, however, provide more options for doctors, hospitals and providers.

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HPAPI contract manufacturing to value $14.6 billion by 2030

European Pharmaceutical Review

The high potency active pharmaceutical ingredient (HPAPI) contract manufacturing market is expected to grow from $7.32 billion in 2022 to $14.65 billion by 2030, according to a market report. This growth is driven by the increased demand for oncology drugs, advances in manufacturing technology and a rise in targeted therapies. There has been a boost in the outsourcing activities of high potency active pharmaceuticals as it removes the need for investment in expensive infrastructure, the report s

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Novo Nordisk acquires Forma Therapeutics for $1.1bn

Pharmaceutical Technology

Novo Nordisk has concluded the acquisition of all outstanding shares of common stock of clinical-stage biopharmaceutical company Forma Therapeutics for $20 for each share in cash or a deal totalling $1.1bn. In September, Novo Nordisk entered a definitive agreement to acquire Forma. With the conclusion of the merger, Forma became Novo Nordisk’s fully-owned subsidiary. .

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How to Stay Competitive in the Evolving State of Martech

Marketing technology is essential for B2B marketers to stay competitive in a rapidly changing digital landscape — and with 53% of marketers experiencing legacy technology issues and limitations, they’re researching innovations to expand and refine their technology stacks. To help practitioners keep up with the rapidly evolving martech landscape, this special report will discuss: How practitioners are integrating technologies and systems to encourage information-sharing between departments and pr

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Emerging Trends in Orthopedic Medical Device Industry

Medico Reach

Grand View Research published a report recently that captured some interesting highlights about the orthopedic medical device industry. The article puts the global market size for the sector at $40.9 billion in 2021, with a compounded annual growth rate (CAGR) of 3.1% from 2022 to 2030. According to another study , musculoskeletal conditions, currently affecting 1.71 billion people, will drive the market revenue even higher.

Medical 98
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NeuroFlow raises $25M to scale behavioral health integration tech

MedCity News

NeuroFlow, a Philadelphia-based provider of behavioral health integration software, recently raised $25 million in growth capital. The startup differentiates itself from the sea of mental health-focused startups in the digital health world because of its ability to combine effective patient engagement technology with decision support tools for clinical staff, according to COO Adam Pardes.

Patients 128
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Shingles vaccine offers a decade of protection in older adults

European Pharmaceutical Review

GSK announced Shingrix (Zoster Vaccine Recombinant, Adjuvanted), the first approved shingles vaccine to combine a non-live antigen with a GSK-made adjuvant, can prevent shingles (herpes zoster) for at least decade. Dr Javier Díez-Domingo, Principal Investigator for FISABIO (Foundation for the Promotion of Health and Biomedical Research of the Valencian Community, Spain), explained: “We can now – for the first time – confirm that the clinical benefit of the vaccine continues for at least 10 years

Safety 105
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Indegene Acquires CultHealth, a Full Service, Healthcare Marketing Agency to Elevate Brand Experience

PharmExec

The acquisition by ILSL Inc., a subsidiary of Indegene Private Limited, augments Indegene’s commercialization portfolio spanning drug discovery and development to marketing and sales, adding brand strategy, market development capabilities, and patient engagement platforms.

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time