Mon.Dec 18, 2023

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Charles River snags clearance to produce Vertex and CRISPR's Casgevy from Tennessee plant

Fierce Pharma

Following a string of approvals in the United States and beyond, Vertex Pharmaceuticals continues to build out its manufacturing network for the world’s first CRISPR-based gene therapy, Casgevy.

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Illumina’s Antitrust Battles to End With Divestiture of Cancer Test Maker Grail

MedCity News

Illumina has decided against further appeals of U.S. and European antitrust litigation challenging its acquisition of liquid biopsy company Grail. Illumina expects to have terms of the divestiture set by the end of the second quarter of 2024.

Biopharma 126
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GSK tees up AstraZeneca rivalry with positive Jemperli-Zejula readout in endometrial cancer

Fierce Pharma

On a mission to grow in oncology, GSK has more positive data to report in endometrial cancer. | GSK has more positive data to report in endometrial cancer as the company's PD-1/PARP combination turned in a trial win. The combination could represent a threat to a rival therapy at AstraZeneca.

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Psilocybin-assisted therapy reduces depressive symptoms in cancer patients

European Pharmaceutical Review

Findings from a small Phase II clinical trial indicate that psilocybin, a hallucinogenic chemical found in certain mushrooms of the genus Psiloybe , may benefit individuals with cancer and major depression. The open-label trial involved 30 adults with cancer and major depression and was conducted by Sunstone Therapies in Rockville, Maryland. The participants each received a single 25mg dose of synthesised psilocybin, a one-to-one session with a therapist and group therapy support.

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AI Strategies for Sales Managers: How to Cut Down on Tedious Admin Work

What if you could help your sellers stop wasting 72% of their day on non-selling activities and focus on bringing in revenue? Incorporating AI in your enablement workflows can help you cut down on busy work, get projects done faster, and let your team (and you!) focus on making a bigger impact. We put together this guide to show you how to use AI to cut time and costs for projects, including collateral creation, development of training videos, and automating tedious processes.

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Bristol Myers Squibb's Opdualag comes up short in late-stage colorectal cancer trial

Fierce Pharma

Bristol Myers Squibb’s PD-1/LAG3 combo Opdualag has more than proved its worth in melanoma since its first-in-class approval in 2022. | The company opted to cut the phase 3 Relativity-123 study after an analysis found that the trial was unlikely to achieve its primary endpoints in microsatellite-stable patients with metastatic colorectal cancer.

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A Look Back: The Life Sciences Industry in 2023 and a View for 2024

PharmExec

In the coming year, efficiency and automation will take center stage to maximize constrained resources but balancing sensible financial management with strategic investments will be vital.

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Why a Former ONC Chief Thinks TEFCA Is Inherently Flawed

MedCity News

Last week, the ONC announced that TEFCA had finally gone live. This followed years of the ONC heralding the project’s potential to boost interoperability and increase patients’ access to their healthcare data. However, former ONC Chief Don Rucker believes that TEFCA is built on an archaic data exchange protocol that will prevent the initiative from being useful.

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Merck, Astellas and Pfizer bring down the house with Keytruda-Padcev FDA nod in bladder cancer

Fierce Pharma

The FDA has signed off on Astellas and Pfizer’s Padcev in combination with Merck’s Keytruda as a first-line treatment for bladder cancer.

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$260 million funding injection for Danish vaccines initiative

European Pharmaceutical Review

The Novo Nordisk Foundation has committed up to DKK 1.8 billion ($260 million) to establish a state-of-the-art research and vaccine development initiative in Denmark. Developed in partnership with the University of Copenhagen and Denmark’s Statens Serum Institut , the Foundation says this the first vaccines initiative globally to focus solely on understanding how to generate immunity in the airway itself.

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CHMP backs Biogen’s Skyclarys for Friedreich’s ataxia

pharmaphorum

Biogen’s Skyclarys is on course to becoming the first approved medicine for the inherited neurological disease Friedreich’s ataxia (FA) in the EU after it was recommended by the EMA’s human medicines committee.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Nursing’s Mental Health Pandemic, and How We Can Stop It

MedCity News

Applications for registered nurse and advanced practice registered nurse licensure too often contribute to this stigma and prevent nurses struggling with mental health issues from getting needed help.

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Trends shaping the pharmaceutical industry in 2024

PharmaVoice

Advancements in cloud and AI technology will transform clinical trial efficiency and engagement.

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How Corporate Healthcare is Leading on Value-Based Care

MedCity News

Value-based care depends on keeping a total population of patients healthier and less in need of higher-cost services. To do so, organizations must be able to predict costs in advance, better understand patient risks, and manage the cost of services. Corporate healthcare is set up to do just that.

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Year in review: EPR’s top stories of 2023

European Pharmaceutical Review

At the beginning of this year, EPR reported on the potential blockbuster pharmaceutical drugs to watch in 2023. Since then, EPR has covered developments for several of the therapies highlighted in the report. This includes the National Institute for Health and Care Excellence (NICE)’s recommendation of the first treatment for Parkinson’s disease, Produodopa (foslevodopa–foscarbidopa).

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How to Prove Marketing Value: Demonstrate Content ROI and Contribution to Sales

Every marketer knows how important it is to prove their efforts drive sales opportunities, but that’s easier said than done. When problems like sales and marketing misalignment, lack of data, and wasted efforts persist, marketers can’t measure, prove, or increase their impact on revenue at a time when demonstrating marketing value is critical. Using analyst and expert data, this guide to marketing impact and content attribution explains: How B2B buyers use content The most common types of conten

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What Do Physicians Really Think of AI?

MedCity News

Nearly half of physicians are equally excited and concerned about the use of AI in their field, according to a new AMA survey. Those who felt optimistic about AI cited reduced administrative burden as the number one benefit they’re seeking. Patient privacy and the impact to the patient-physician relationship were the most common reasons physicians cited for having reservations about AI.

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The Price of Prescriptions: Getting it Right

PharmExec

Drug companies face new hurdles in a rapidly changing marketplace. How do they finance new drug development amid the uncertainty?

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Elevating Patient Experience Through Informed Decision-Making [Sponsored]

MedCity News

Informed decision-making is crucial to operational efficiency, which fundamentally impacts the patient experience, but how do you facilitate it?

Patients 110
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Vertex secures CHMP nod for Casgevy approval in Europe

Pharmaceutical Technology

Following US and UK approvals, the EMA’s CHMP has recommended conditional approval for Casgevy, with a decision expected in Q1 2024.

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Optimizing Clinical Supply Strategy: Navigating Challenges & Finding Your Ideal Model

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Point Bio Prostate Cancer Therapy Meets Phase 3 Goal, But Results Still Disappoint

MedCity News

Despite achieving its Phase 3 study’s main goal, the results for Point Biopharma’s therapy are short of what Novartis radiopharmaceutical Pluvicto achieved in a similarly designed clinical trial. Nevertheless, the data readout should clear the way for Eli Lilly to complete its $1.4 billion acquisition of Point.

Biopharma 102
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Eisai files biliary tract cancer drug tasurgratinib in Japan

pharmaphorum

Eisai files for approval in Japan for FGFR inhibitor tasurgratinib as a treatment for biliary tract cancers with FGFR2 gene fusions

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HHS Launches New Medicaid Care Model To Improve Maternal Health Outcomes

MedCity News

HHS announced a new care model that aims to provide mothers with Medicaid coverage with more personalized maternal health care. This includes access to doulas and midwives and screening for health-related social needs.

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New RUBY readout buoys GSK’s Jemperli in endometrial cancer

pharmaphorum

RUBY Part 2 trial of GSK's PD-1 inhibitor Jemperli and PARP inhibitor Zejula could open up wider use in first-line endometrial cancer

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Increase Revenue With Better, Faster Sales Onboarding

Quotas need to be hit. Revenue goals need to be met. This reality makes shortening sales onboarding time a top priority. Organizations with a standard onboarding process boost employee retention by 58% and increase productivity by 50%. Unfortunately, many companies struggle with inefficient processes that lead to high turnover and missed revenue opportunities.

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Season Health Snags $7M for Food-as-Medicine Platform

MedCity News

Season Health has secured a $7 million investment from Inception Health and Ziegler Link-age Fund. The financing will be used to develop and scale its food-as-medicine programs, including for diabetes and high-risk pregnancies.

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Cognitive decline in early Alzheimer’s could stem from serotonin loss

PharmaTimes

MCI patients had 25% lower levels of serotonin compared to healthy patients Researchers from Johns Hopkins Medicine have suggested that serotonin loss in parts of the brain may play a role in cognitive decline in the early stages of Alzheimer’s disease (AD). Published in the Journal of Alzheimer’s Disease , the study was supported by other contributing scientists from the Johns Hopkins University School of Medicine and the Johns Hopkins Bloomberg School of Public Health.

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Illumina admits defeat in Grail quest, opting to divest

pharmaphorum

Illumina will divest cancer detection company Grail after losing an appeal in an antitrust court case in the US

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Novo Nordisk Foundation sets up airborne infection vaccine initiative

Pharmaceutical Technology

The Novo Nordisk Foundation has invested Dkr1.8bn in the initiative to develop vaccines for various airborne infection diseases.

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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Cognitive decline in early Alzheimer’s could stem from serotonin loss

PharmaTimes

MCI patients had 25% lower levels of serotonin compared to healthy patients - News - PharmaTimes

Patients 109
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ACG Inspection Presents New VRS

Pharmaceutical Commerce

Cloud-based service to address verification of saleable returns under the latest DSCSA regulations.

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Digital health collaboration to trial AI-powered X-rays for lung cancer detection

PharmaTimes

Earlier diagnosis could increase patient survival rates by five years or more - News - PharmaTimes

Patients 107
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Asset Service Management: Why It’s So Important to Field Service

Salesforce

Think about what could happen if you don’t have a good handle on your field service assets. Without a proper process in place, you risk operational inefficiencies, increased costs, and a decline in overall performance. You might even jeopardize the safety of your employees, contractors , and customers. Enter asset service management, the process of effectively managing and maintaining physical assets in field service.

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Using Generative AI in Sales: Pros, Cons, and Considerations According to Sellers

Are your sellers unsure about using AI in their day-to-day workflows? Or are they eager to try but uncertain where to start? They might be asking: Which tasks are best suited for AI? How will using AI affect my relationship with my customers? With so many tools available, which ones are the most useful to me? To help answer these and other common questions about using AI during the sales cycle, we surveyed B2B sellers who were early adopters to get their insight and advice about how to use gen A