Thu.Jan 04, 2024

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Novo Nordisk, Eli Lilly's weight-loss drugs under FDA scrutiny for suicidal thoughts, hair loss

Fierce Pharma

Use of Novo Nordisk and Eli Lilly’s popular diabetes and weight loss drugs come with warnings about a rare intestinal blockage condition called ileus, which can be life threatening. | Use of Novo Nordisk and Eli Lilly’s popular diabetes and weight loss drugs come with warnings about a rare intestinal blockage condition called ileus. Could cautions about more common side effects soon be added to the labels of popular treatments such as Novo’s Ozempic and Lilly’s Mounjaro?

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Trial Data Looks Promising for ‘IUD For Men’

MedCity News

Contraline released promising data from the clinical trial it’s conducting to test the efficacy of Adam, its male birth control product. The nonhormonal gel seems to be doing a good job of blocking the flow of sperm to the vas deferens, and no serious adverse events have been reported.

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2024 forecast: As CDMOs come off pandemic's highs and lows, employment and funding hitches persist

Fierce Pharma

Even after the heady highs of the COVID-19 era, the contract development and manufacturing organization (CDMO) realm remains one of biopharma's buzziest fields. | Even after the heady highs of the COVID era, the CDMO realm remains one of biopharma's buzziest fields. In 2024, CDMOs can advance their priorities on three fronts, a group of experts said during a recent Evaluate webinar on the state of the industry.

Biopharma 285
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Regulatory revision essential for bioprocess IIoT adoption

European Pharmaceutical Review

According to a paper recently published in the Biochemical Engineering Journal , challenges such as strict regulation and lack of industry awareness, limit the adoption of Industrial Internet of Things (IIoT) in bioprocessing and overall bioproduction. As a system that uses various technologies , such as data analytics and artificial intelligence (AI), to transfer data between each other autonomously in an industrial setting, IIoT “enables wide-scope data collection and utilisation, and reduces

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AI Strategies for Sales Managers: How to Cut Down on Tedious Admin Work

What if you could help your sellers stop wasting 72% of their day on non-selling activities and focus on bringing in revenue? Incorporating AI in your enablement workflows can help you cut down on busy work, get projects done faster, and let your team (and you!) focus on making a bigger impact. We put together this guide to show you how to use AI to cut time and costs for projects, including collateral creation, development of training videos, and automating tedious processes.

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Bluebird bio's Lyfgenia launch progresses with 2nd major outcomes-based coverage deal

Fierce Pharma

Despite competitive pressure from a buzzy CRISPR therapy, bluebird bio keeps striding forward with its sickle cell disease gene therapy Lyfgenia. | Despite competitive pressure from a buzzy CRISPR therapy, bluebird bio has signed a second outcomes-based reimbursement agreement for its sickle cell gene therapy Lyfgenia.

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Star Ratings are Great for Finding a Good Restaurant; They Can Be Deadly if You Are Shopping for a Doctor

MedCity News

Patient Reported Outcome Measures (PROM) scores should be the gold standard for how patients find their doctors, not viewing subjective online reviews of doctors’ ability to satisfy their patients.

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Both Have Done Wrong, Expert Says On UHC/Mount Sinai Contract Dispute

MedCity News

Mount Sinai is out of network for UnitedHealthcare’s employer-sponsored and individual plans as of January 1 due to a payment dispute. Both parties are likely at fault for getting to this point, one expert declared.

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CVS Caremark to kick AbbVie's Humira off some formularies in favor of cheaper biosimilars

Fierce Pharma

This year, CVS Health plans to employ the classic "out with the old, in with the new" mantra when it comes to AbbVie’s Humira. | The changes to major commercial formularies will take effect April 1 and favor Humira biosimilar options over the branded drug as part of CVS' efforts to ramp up U.S. biosimilar adoption.

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FDA Grants Fast Track, Breakthrough Designations to CG Oncology Inc’s Cretostimogene Grenadenorepvec

PharmExec

Cretostimogene grenadenorepvec (CG0070) is currently being evaluated for the treatment of patients with high-risk Bacillus Calmette-Guérin–unresponsive non–muscle invasive bladder cancer with carcinoma in situ with or without Ta or T1 tumors.

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Bain Capital eyes potential €1B sale of Dutch antibiotics manufacturer Centrient: report

Fierce Pharma

As bankers predict a rise in private equity exits this year, one of 2024’s M&A moves could come from the drug manufacturing realm. | Investment giant Bain Capital is weighing a potential sale of its Dutch antibiotics and active pharmaceutical ingredients (API) specialist Centrient Pharmaceuticals, which could be valued as high as €1 billion ($1.09 billion), Bloomberg reported Wednesday, citing people close to the talks.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Roche antibiotic tackles serious drug-resistant pathogen

pharmaphorum

Scientists at Roche and Harvard University have discovered a new class of antibiotic that can kill carbapenem-resistant Acinetobacter baumannii (CRAB), a major public health threat

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Merck settles with insurance companies over $1.4B claim tied to 2017 cyberattack: report

Fierce Pharma

Merck has reportedly settled with insurance companies that contested the pharma giant’s $1.4 billion claim after it was victimized by a crippling cyberattack in 2017. | Merck has settled with insurance companies that contested the pharma giant’s $1.4 billion claim after it was victimized by a crippling cyberattack in 2017, Bloomberg Law reports. With the settlement—terms of which were not disclosed—the insurance companies avoided a ruling that would have provided precedent for other cases involv

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Click bags FDA breakthrough tag for schizophrenia DTx

pharmaphorum

Digital health company Click Therapeutics has won an FDA breakthrough device designation for CT-155, a digital therapeutic (DTx) for the negative symptoms of schizophrenia, like social withdrawal and apathy, that tend not to respond well to antipsychotic drugs.

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Leading a New Era of Patient-Inspired Neuroscience

Fierce Pharma

Article by Richard Pops, CEO of Alkermes | Alkermes, a pioneer in neuroscience therapeutics, is building on its foundation as it emerges as a pure neuroscience company.

Leads 228
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How to Prove Marketing Value: Demonstrate Content ROI and Contribution to Sales

Every marketer knows how important it is to prove their efforts drive sales opportunities, but that’s easier said than done. When problems like sales and marketing misalignment, lack of data, and wasted efforts persist, marketers can’t measure, prove, or increase their impact on revenue at a time when demonstrating marketing value is critical. Using analyst and expert data, this guide to marketing impact and content attribution explains: How B2B buyers use content The most common types of conten

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Hospitals Finally Reached Widespread Price Transparency Compliance in 2023

MedCity News

Hospitals markedly improved their compliance with price transparency regulations in 2023, according to a new report. It found that more than 90% of hospitals have posted a machine-readable file containing gross charges, negotiated charges and cash prices for the services and items they provide.

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Preventative approach could reduce immunotherapy side effects

European Pharmaceutical Review

New research from the US indicates that a prophylactic treatment before immunotherapy can significantly reduce the rate of cytokine release syndrome (CRS) in multiple myeloma patients. Immunotherapy drugs like teclistamab can result in potentially fatal side effects, including CRS and immune cell-associated neurotoxicity syndrome (ICANS). Prophylactic treatment as a preventative measure The new study, published in Blood Cancer Discovery , stated that in the future, this could eliminate the need

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NewSpring Closes 4th Healthcare Fund At Over $180M

MedCity News

NewSpring has closed on its fourth healthcare fund, which raised more than $180 million. It has already made six investments, including Healthworks and BetterNight.

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Novel drug delivery method shows promise in Alzheimer’s

European Pharmaceutical Review

US researchers have demonstrated the potential of a targeted drug delivery method that uses focused ultrasound in combination with anti-amyloid-beta monoclonal antibody treatment, as a way to accelerate brain amyloid-beta plaque clearance in Alzheimer’s. The paper, published in the New England Journal of Medicine , described that in the first-in-human study, the focused ultrasound system was able to safely and temporarily open the blood-brain barrier to allow the anti-amyloid-beta antibodies inc

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Optimizing Clinical Supply Strategy: Navigating Challenges & Finding Your Ideal Model

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Novo Nordisk’s Flagship alliance bears obesity, MASH fruit

pharmaphorum

Novo Nordisk has reaped the first harvest from its wide-ranging alliance with life sciences investor Flagship Pioneering, buying rights to two programmes from the VC’s portfolio companies Omega Therapeutics and Cellarity.

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Rethinking Healthcare: Navigating the Uncomfortable Path of Value-Based Care

MedCity News

In aggregate, value based care has yet to produce the consistent, positive results that we seek. But VBC’s slow start is actually a reflection of the difficulty of transitioning away from our entrenched healthcare compensation system.

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AbbVie hit as CVS says it will cut Humira from formularies

pharmaphorum

CVS Health will remove AbbVie’s immunology blockbuster Humira from national lists of reimbursable products, and offer biosimilars of the drug instead

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Will General Catalyst’s Health Assurance Transformation Corporation (HATCo) Model Work in 2024?

MedCity News

The model will be challenging to implement since the expansive vision and cautious operational model don’t naturally align. But it could see positive reactions from the clinician community which – while seeing the need for change and technological innovation – is deterred by visions of disruption at the operational or at more granular, process levels.

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Increase Revenue With Better, Faster Sales Onboarding

Quotas need to be hit. Revenue goals need to be met. This reality makes shortening sales onboarding time a top priority. Organizations with a standard onboarding process boost employee retention by 58% and increase productivity by 50%. Unfortunately, many companies struggle with inefficient processes that lead to high turnover and missed revenue opportunities.

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Vicore Pharma DTx helps pulmonary fibrosis patients

pharmaphorum

A digital therapeutic developed by Vicore Pharma and Alex Therapeutics has been shown to reduce anxiety in patients with pulmonary fibrosis in a pivotal trial

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Pfizer receives Health Canada approval for haemophilia B therapy

Pharmaceutical Technology

Pfizer Canada has received Health Canada approval for gene therapy Beqvez (fidanacogene elaparvovec) for the treatment of haemophilia B.

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Electronic Health Record Messaging Patterns of Healthcare Providers

Pharmaceutical Commerce

Electronic health record messaging network found to improve communication and lead to better medication adherence.

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Merck bets on Inspirna’s colorectal cancer drug ompenaclid

pharmaphorum

German pharma Merck has paid $45m upfront to license a potential first-in-class therapy for colorectal cancer from New York biotech Inspirna

Pharma 95
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European Clinical Supply Planning: Balancing Cost, Flexibility and Time

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Risk model predicts response and survival of cancer patients treated with ICIs

PharmaTimes

Metastatic cancer is estimated to be responsible for 90% of cancer deaths

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Boehringer targets NASH/MASH with $2bn Ribo alliance

pharmaphorum

Boehringer Ingelheim has signed a collaboration with China’s Ribo to develop treatments for NASH/MASH using siRNA drugs

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Disrupted sleep could be associated with cognitive function changes

PharmaTimes

High amounts of disrupted sleep were found to affect memory and thinking performance

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Alzheimer’s research is hot, but successful patient recruitment will determine its future

PharmaVoice

Key strategies for bringing more patients into the clinical trial fold.

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Using Generative AI in Sales: Pros, Cons, and Considerations According to Sellers

Are your sellers unsure about using AI in their day-to-day workflows? Or are they eager to try but uncertain where to start? They might be asking: Which tasks are best suited for AI? How will using AI affect my relationship with my customers? With so many tools available, which ones are the most useful to me? To help answer these and other common questions about using AI during the sales cycle, we surveyed B2B sellers who were early adopters to get their insight and advice about how to use gen A