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Researchers have developed a physics-enhanced autocorrelation-based estimator (PEACE) machine learning algorithm that can extract the particle size distribution (PSD) of a pharmaceutical powder surface from its laser speckle. This limits its application to surfaces encountered in pharmaceuticalsmanufacturing.
The first industrial-scale pharmaceuticalmanufacturing facility for production of lead-212-based radioligand therapies has been inaugurated. During the earlier announcement for its French facility, Orano Med highlighted one key challenge of developing lead-212 based radioligand therapies is manufacturing then on an industrial scale.
Contract research, development and manufacturing organisation (CRDMO) WuXi STA has broken ground on its new 190-acre pharmaceuticalmanufacturing campus in Middletown, Delaware, US. WuXi STA has 12 sites across the US, Europe and Asia. WuXi STA has 12 sites across the US, Europe and Asia.
There has been a steady stream of developments in the vaccine manufacturing space throughout 2023. A notable milestone was Moderna’s announcement in April that it had, following finalisation of a ten-year strategic partnership with the UK Government, commenced construction of its mRNA vaccine manufacturing technology centre.
Three trade bodies representing vaccine creators and manufacturers are endorsing The Berlin Declaration framework , a proposal that outlines how the industry would reserve an allocation of real-time vaccine production for swift distribution to priority populations in lower-income countries in future pandemics.
How pharmaceuticalmanufacturers should consider their Fair Market Value cost assessment compared to their negotiation leverage when contracting for distribution services
How pharmaceuticalmanufacturers should consider their Fair Market Value cost assessment compared to their negotiation leverage when contracting for distribution services
To appreciate the scope of the challenge facing the pharmaceutical market, as well as patients across the globe, we must understand that there are two distinct threats – ‘counterfeit’ and ‘falsified’ medicines. These may be mislabelled or produced in fake packaging and, most dangerously, there is no regulation around their manufacture.
Processes in pharmaceuticalmanufacturing such as processing, milling, grinding, and mixing, are associated with the generation of dust. The researchers highlighted that the risks of hazard exposure include danger to the health of operators and cross-contaminations during manufacturing.
From the manufacturer perspective, payer policies and legislation on combination therapy pricing are impacting global development, pricing, access, and commercialization strategies. As a result, manufacturers are increasingly opting to not launch their combination indications in certain markets.
Additionally, OSD manufacturing approaches are well developed, with processes that ensure a repeatable distribution of ingredients, uniformity in dissolution, and bioavailability, which verify that the drug product is safe and effective. Compared to other dosage forms, tablets are simpler to manufacture, package, and transport.
Pharmaceutical wholesalers act as intermediaries between pharmaceuticalmanufacturers and retailers and facilitate the delivery of the right medicines in a timely, efficient, and secure manner. Discover the top pharmaceutical wholesalers. GDP and GMP advisory. Temperature control facilities and supply solutions.
Ben Hargreaves discovers why some have referred to the distribution of COVID-19 vaccines and treatments as a form of apartheid. Further, with a pandemic treaty in development, there are reasons to believe that many countries and the WHO want to see a more equitable distribution of medical products for future pandemics.
Pharmaceutical Technology has listed the leading commercial dose non-sterile companies in contract marketing based on its intel, insights, and decades of experience in the sector. The post Leading commercial dose (non-sterile) companies in contract marketing appeared first on Pharmaceutical Technology.
Manufacturer assistance programs are designed to make treatments more affordable, yet only about 10% of these dollars are used by patients. Pharmaceuticalmanufacturers know how important adherence to a treatment plan is and to help patients afford medications, manufacturer assistance programs are designed to make treatments more affordable.
While India and Italy are known for their active pharmaceutical ingredient (API) industries and production of generic drugs, other countries such as Brazil, Canada, South Korea, and others also have provisions for the manufacture and sale of generic drugs before the patent expires. of gross domestic product (GDP).
During this stage, a team of lab technicians must identify the best way to manufacture the active pharmaceutical ingredient (API) into a suitable dosage form for pilot production. If clinical trials prove successful, that same process should then be scaled to commercial manufacturing.
The pharmaceutical industry requires specialised and cost-effective commercial packaging solutions to improve efficiency and preserve the integrity of products through the entire supply chain, from primary packaging and labelling to shipping, delivery, storage and distribution to end users.
In the US solid dosage forms are distributed as containers of tablets and these can only be coded on the container and not on a per-item basis. ” LEVEL TRACKING Pharmaceuticalmanufacturing company Seidenader Vision has also developed a system – the SATrack and Trace.
Shanghai Fosun Pharmaceutical (Group) is to collaborate with the International Finance Corporation (IFC) to construct a new pharmaceutical production facility and distribution hub near Abidjan, Côte d’Ivoire. The IFC will provide two loans totalling $53.49m (€50m) to Fosun Pharma’s subsidiaries.
Although the driving factors of the shortage are complex, the bottom line is that drug manufacturers, particularly those that produce generic drugs, can’t afford to stockpile raw materials and products to prepare for shortages due to financial, storage capability, and product expiry limitations.
Sanofi has signed definitive agreements with Adragos Pharmaceutical, a German contract development and manufacturing organisation (CDMO), for the sale of its pharmaceuticalmanufacturing site in Kawagoe, Japan. The French pharmaceutical company will also enter into a long-term supply agreement with the CDMO.
The pandemic effectively shut down supply chain paths overnight, and as a result, pharmaceuticalmanufacturers have faced delays and bottlenecks, which have caused drug shortages in healthcare systems. Above all else, manufacturers need to get their houses in order. The stakes are high. Logistical challenges.
Amidst numerous warning letters distributed by the US Food and Drug Administration (FDA) to pharmaceuticalmanufacturers in recent months, in July this year, the US regulatory body published its analysis on drug product quality in 2022. Eight FDA warning letters were handed to European companies in 2018. Edge Biologicals Inc.,
The WHO called on key stakeholders, including regulators, governments and manufacturing facilities, to take immediate and coordinated action. In this instance of contaminated cough syrups, the concern is around an excipient in the product and not the active pharmaceutical ingredient (API).
1 In pharmaceuticalmanufacturing, the high level of final product quality is the major driver. Tablets should be defect-free and compliant to good manufacturing practice (GMP) aspects and final-user requirements. In tablet compression, there are a range of factors which contribute to a successful production run.
Manufacturing delays and capacity issues that continue to impact the pharmaceutical supply chain have led to medicine shortages around the globe; an issue that has been exacerbated further by geopolitical events, the energy crisis and rising inflation. Globalisation and supply chain complexity are a factor.
The pharmaceutical supply chain is a global and complex network that includes a wide range of stakeholders such as pharmaceuticalmanufacturers, wholesale distributors, and pharmacy benefit managers (PBM), to ensure efficient and timely delivery of medications to the patients.
In an age of disruption, technology is key to enabling pharmaceuticalmanufacturers monitor, track and control shipments and their processes. Pharmaceutical firms are changing the way they do business; the future winners will be highly automated and digitalised. But this results in huge, complex datasets.
The US Food and Drug Administration (FDA) believes the adulteration of heparin was an economically motivated act—a clear breach of the US pharmaceutical supply chain. In other words, money over safety. Can patients really be confident in pharma supply chains?
International companies investing in the emerging market of Brazilian pharmaceuticalmanufacturing will see a higher return on investment than from developed market equivalents, if they choose to compete with local manufacturers to supply Brazil’s growing market and the greater South American region.
Although the reported negotiated prices may ignore the real-world role of contracting by manufacturers and private payers over formulary placement, the reported prices nonetheless are likely to have downstream impacts on how private payers reimburse these therapies and their competitors.
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