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High risk, high reward – the future of CAR-T therapy in CLL

Pharmaceutical Technology

According to GlobalData’s analyst consensus forecast, Yescarta is expected to reach peak sales of $1.8bn in 2028, and Kymriah is expected to reach sales of $686m in the same year. Autologous CAR-T agents are now becoming the standard of care for patients in the third line and later settings, providing lucrative returns for these agents.

Patients 111
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Key developments in pharmaceutical manufacturing – September 2023

European Pharmaceutical Review

AstraZeneca’s facilities in Macclesfield, the UK’s largest pharma manufacturing site, as well as Cambridge, Luton and Speke will all be supplied by energy from the new facility, which is currently being built. Astellas – sustainable innovation September also saw Astellas Pharma Inc. Kerry, Ireland.

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6th Annual 3D Cell Culture Conference

pharmaphorum

Billion by 2028. Billion by 2028. The pharmaceutical industry globally is realising the growing potential of in vitro tissue models for drug discovery, pathology modelling and validation, safety and toxicity. Exploring the implementation of complex in-vitro models for drug development. Who Should Attend?

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Key Developments from AMCP 2023 on Blockbuster Generics, Diabetes Drugs, PBM Legislation, and More

PM360

Under the pathway, manufacturers can use safety and efficacy data from existing products in their applications for their own products. The product, manufactured by ARS Pharma and Neurelis Pharma, would be the first needle-free epinephrine alternative to autoinjectors, such as the EpiPen.

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PROTAC development gains momentum, but clinical performance is poor

Pharmaceutical Technology

According to the GlobalData Pharma Intelligence Center, there are currently 71 PROTACs in development in the oncology pipeline by non-academic developers, mostly clustering in the preclinical and discovery phases, with only 14 agents in clinical stages. Both degraders, ARV-110 (bavdegalutamide) and ARV-766, are being developed by Arvinas.

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Five points on CMS’s first ten picks for price negotiations

Clarivate

The dearth of cancer drugs (only blood cancer drug Imbruvica made this first list) stems from CMS only pursuing negotiations for Part D drugs in 2026 and 2027, then expanding to Part B drugs in 2028. Part D cannot cover drugs covered under Part A or Part B , forcing them to be addressed separately.

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The U.S. health insurance market is undergoing a post-pandemic sea change

Clarivate

In March 2024, New York received approval for a five-year Medicaid expansion through April 1, 2028, extending eligibility to include individuals with incomes up to 250% of the federal poverty level (eligibility was previously capped at 200%).