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MHRA Chief Executive to step down

European Pharmaceutical Review

Leading the MHRA – a five year journey Professor Graham Cooke, interim chair of the MHRA board, remarked that Dame June’s “leadership of the MHRA over the last five years, particularly during the COVID-19 pandemic, has been exceptional.” Her previous role in the agency was as Director of Vigilance and Risk Management of Medicines.

Safety 111
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Can Hepatitis C drugs reduce symptoms of PTSD?

European Pharmaceutical Review

The researchers studied 254 VA patients who were diagnosed with PTSD and hepatitis C between October 1999 and September 2019. PTSD is a potentially chronic condition that disrupts lives and can lead to or exacerbate existing health issues such as depression, anxiety, eating disorders, and suicidal thoughts.

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Early diagnosis in Alzheimer’s disease: A first step towards better care

Clarivate

As dementia becomes more severe, people require greater care, and develop complications such as pressure ulcers, infections, dysphagia, malnutrition and aspiration pneumonia – a leading cause of death among people with Alzheimer’s (Anon., Creative Art Therapy as a Non-Pharmacological Intervention for Dementia: A Systematic Review.

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FDA suggests ways to curb constraints with rare disease gene therapy trials

Pharmaceutical Technology

Blank acknowledged that in many cases, an exclusively paediatric patient population could lead to difficulties with drawing consent for early phase trials. Still, Blank suggested that companies enroll the patient population that is most likely to benefit, because early phase studies contain the most safety risks.

FDA 105
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Advancing AOCs to transform the delivery of RNA therapeutics

European Pharmaceutical Review

Known linkers in the RNA field are used to bond together the two pharmacologically active molecular entities and can be applied to multiple oligonucleotide modalities. Research advances are also helping us learn more about how RNA is processed, potentially leading to new strategies to alter dysfunctional RNA. 2019 ;42:385-406.

Safety 98
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Recurrent drug shortages signal onerous outlook for cardiovascular care

Pharmaceutical Technology

This is due to aging populations around the world, which leads to an increased risk of such conditions, explains Craig Beavers, PhD, assistant professor at the University of Kentucky’s College of Pharmacy in Lexington. Also, substitution can lead to further shortages, he adds. Critical care especially hit.

Medicine 111
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Why R&D innovation holds the key to greater patient impact

European Pharmaceutical Review

Cancer remains a global threat with around 10 million people dying from the disease each year worldwide, making it the second leading cause of death. About the authors Dr Nils Eckardt joined BeiGene in February 2019 as Vice President, Medical Affairs, Europe. 2019 [cited 2023 Apr 4]. 1,2 In the EU, an estimated 2.7

Patients 105