European Pharmaceutical Review

MAY 23, 2024

Since 2017, six CAR-T cell therapies have been approved by the US Food and Drug Administration (FDA) for the treatment of blood cancers, including lymphomas, some forms of leukaemia, and, most recently, multiple myeloma. CAR T-cell Therapy and its side effects [Internet]. 2 Why does CARVYKTI have potential in multiple myeloma?

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European Pharmaceutical Review

JUNE 12, 2024

The specific representation of these events differed between the treatments, highlighting potential differences in side effect profiles that should be explored in further studies. 2017; 55(7):1998-2008. Adverse events were relatively low in both groups (2.22 percent for MBK-01 and 4.26 percent for fidaxomicin). J Clin Microbiol.

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pharmaphorum

DECEMBER 23, 2022

But along with strong efficacy come some considerable risks and costs: cytokine release syndrome (CRS), where a patient’s immune system becomes dangerously over-stimulated, and neurotoxicity are potential side effects that need to be managed. Side effects and cost implications.

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Side effects Patients Medical Medicine 52

European Pharmaceutical Review

JULY 5, 2022

There is an urgent need for more effective chemotherapy treatments with less severe toxicity and side effects. Irinotecan – also known by the brand name Campto/Camptosar ® (Pfizer Ltd.) – has proven to be an effective chemotherapy agent against several types of gastrointestinal cancer. 2017; 8(23):38022-38043.

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Patients Food and Drug Administration Side effects Safety 104

Pharmaceutical Technology

JANUARY 27, 2023

Briumvi is the third approved injectable MS treatment directed against CD20 antigen expressed on B cells, with the other therapies being Kesimpta (ofatumumab, approved in 2020) and Ocrevus (ocrelizumab, approved in 2017). All three treatments are monoclonal antibodies. Some 48% of patients on Briumvi also suffered with infusion reactions.

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Marketing Side effects Safety Patients 52

European Pharmaceutical Review

OCTOBER 19, 2023

One aspect that is extremely promising about radiopharmaceutical therapeutics is that they do not give a patient the side effects that are commonly experienced with chemotherapy. His research lab focused on second generation targeted radiotherapeutics which became the core technology of Noria Therapeutics, a company he started in 2017.

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Food and Drug Administration Manufacturing Side effects Doctors 105

Clarivate

SEPTEMBER 25, 2024

A ‘magic bullet’ medicine that can cure a disease quickly and completely, [1] without deleterious side effects. [2] 6] As many pathogenetic targets have multiple physiological functions, highly specific ‘magic bullets’ may impact multiple cellular pathways simultaneously, causing unintended side effects.7 Chin J Cancer.

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pharmaphorum

JANUARY 3, 2023

” Rawlins was knighted in the 1999 Queen’s New Year Honours for services to the improvement of patient protection from the side effects of medicines, and in 2017 was appointed Knight Grand Cross of the Order of the British Empire (GBE) for services to the safety of medicines, healthcare, and innovation.

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European Pharmaceutical Review

AUGUST 24, 2022

The ultimate goal of the ADC concept is to maximise the potency of treatment and reduce unwanted side effects on healthy tissues. Consequently the market dynamics were slow, with just three approved ADC drugs until 2017. The culmination of two decades of learning.

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Pharmaceutical Technology

APRIL 24, 2023

The combination therapy also caused fewer side effects, with heart problems and hypertension as the most common ones, based on the final draft guidance. CLL is regarded as the most common type of leukaemia in England where 3,157 patients were diagnosed with the disease in 2017, based on the institute’s announcement.

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pharmaphorum

SEPTEMBER 11, 2022

All told, 7% of patients treated with SpringWorks’ therapy had a complete response to treatment, and 95% of side effects liked to the drug were mild (grade 1 or 2), most commonly diarrhoea, rash, and elevated levels of phosphate in the blood.

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Side effects Leads Safety Patients 52

European Pharmaceutical Review

JANUARY 3, 2023

Sensorion, a biotechnology company has announced that the first patient has been enrolled in its NOTOXIS Phase IIa proof of concept clinical trial of SENS-401 (Arazasetron) in cancer patients experiencing cisplatin-induced ototoxicity (permanent hearing loss), a serious side effect of key chemotherapeutic agent cisplatin.

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Patients Food and Drug Administration Side effects Food 52

pharmaphorum

JULY 11, 2022

The company had been eyeing a possible regulatory filing for fitusiran this year, but has now set back the timeline – possibly until 2024 – while it gathers data on the revised dosing schedule, in the hope of maintaining efficacy with fewer clotting side effects.

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Engineering Side effects Competition Sales 52

European Pharmaceutical Review

JANUARY 25, 2024

They detail the medication’s intended use, proper administration, potential side effects and precautions. They are vital to ensuring the safe and effective use of medicines, making them an integral part of healthcare in Europe. Article 63 EMA (29 January 2020).

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Pharmaceutical Technology

AUGUST 12, 2022

They were first licensed for use in 2017 for two forms of blood cancer, acute lymphoblastic leukemia (ALL), and B-cell lymphoma (BCL). However, CAR-T cell therapies have limitations such as relapse or severe autoimmune side effects. Overall, the global CAR-T cell market for all indications was worth $1.7

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Side effects Marketing Engineering Patients 52

pharmaphorum

JULY 26, 2022

NewAmsterdam notes it is highly-potent, so can be delivered at a low dose that should avoid the side effect issues that plagued some earlier candidates, notably Pfizer’s torcetrapib. So why will obicetrapib avoid the pitfalls of its predecessors? Amgen licensed the rights to NewAmsterdam in 2020.

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Side effects Safety Pharma Patients 52

PM360

OCTOBER 22, 2024

And with therapy underway, many of these programs help boost adherence¹ by addressing common barriers to compliance, like missed doses, side effects, and unreliable information about the drug and disease.² Sculpting Seamless Patient Experiences: Five hallmarks of a highly effective patient support program 5.

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Patients Healthcare Provider Pharma Prescription 59

Clarivate

AUGUST 17, 2022

In 2017, the same year the SDGs came into effect, the United Nations found that less than half of the global population was covered by essential health services. What side effects should you contact a doctor about immediately, or what are the risks of a procedure and the likelihood of success?

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Celeritas

NOVEMBER 21, 2022

They only partially impact the target areas and have damaging side effects in adjacent regions. Gold nanowires further positively impact key organ transplant functions – synapse formation and stem cell differentiation – all without using growth factors, which cause negative side effects. References. [1] 1] Subramani K.,

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European Pharmaceutical Review

AUGUST 15, 2024

BTKis, oral drugs given as continuous monotherapy, have revolutionised the treatment of CLL, with the first generation BTKi ibrutinib receiving European Medicines Agency (EMA) approval in 2014; however, side-effects (such as cardiovascular toxicities 2 ) have limited its suitability. 2017; 1(20):1739–48. 2022; 21(1).

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Safety Patients Medical Medicine 52

pharmaphorum

JUNE 28, 2022

aureus bloodstream infections in the US, according to 2017 data from the Centers for Disease Control and Prevention (CDC). in the daptomycin-based therapy group, with no significant differences between the therapies on the overall rate of side effects. There are nearly 120,000 S. The overall success rate was 69.8%

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Contrarian Sales Techniques

FEBRUARY 26, 2023

The paper was presented at the International Conference on Pharmaceutical Research and Development (IPRDC) in Kuala Lumpur, Malaysia, in June 2017. There are some countries in the world that do not require waiting for patent expiration to produce a generic version of a drug. This is true for both developed and developing countries.

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pharmaphorum

SEPTEMBER 14, 2022

For decades, riluzole was the only approved therapy for ALS, with limited efficacy, and it was joined by an intravenous formulation of Radicava in 2017, which according to GlobalData has been hampered by an intense dosing schedule, its route of administration, side effect profile, and high annual cost of therapy.

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Side effects FDA Medical Patients 64

Pharmaceutical Technology

NOVEMBER 30, 2022

A 2017–2018 National Health and Nutrition Examination Survey (NHANES), showed that 30.7% In the past, obesity medications were often dismissed due to insufficient efficacy data and the fact that they were associated with a high occurrence of side effects. The same can be said for the US. of adults were overweight, 42.4%

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Pharmaceutical Technology

NOVEMBER 30, 2022

A 2017–2018 National Health and Nutrition Examination Survey (NHANES), showed that 30.7% In the past, obesity medications were often dismissed due to insufficient efficacy data and the fact that they were associated with a high occurrence of side effects. The same can be said for the US. of adults were overweight, 42.4%

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Medical Manufacturing Insurance Side effects 98

World of DTC Marketing

FEBRUARY 23, 2021

How long do you believe it will be before the media once again runs stories about drug prices or drug side effects? The increase followed total Humira price hikes of 19 percent during 2017 and 2018, according to a survey by the nonprofit Institute for Clinical and Economic Review, which deemed the increases unjustified.

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