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Tackling the complex development landscape of pain medicines

European Pharmaceutical Review

There is a clear trend away from developing pharmacological therapies targeting opioid receptors” There is a clear trend away from developing pharmacological therapies targeting opioid receptors. 2017; 6(S1):1–3. Neuropathic pain in adults: pharmacological management in non-specialist settings – NCBI Bookshelf.

Medicine 102
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NICE to update endometriosis guidelines to improve diagnosis and surgical management

Pharmaceutical Technology

This marks the first update to NICE’s endometriosis guidelines since 2017, representing a huge milestone for patients and practitioners alike. In response to their request, NICE conducted a surveillance review of the 2017 guidelines to evaluate whether their recommendations align with the current research and evidence.

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Early diagnosis in Alzheimer’s disease: A first step towards better care

Clarivate

The pathophysiology of Alzheimer’s is complex and involves multiple mechanisms, including extracellular deposition of amyloid-β (Aβ) plaques and intracellular formation of neurofibrillary tangles (NFT) of tau, causing progressive neuronal loss and atrophy (Counts, 2017). Abbreviations: AD, Alzheimer’s disease; MCI, mild cognitive impairment.

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Novartis drops presbyopia drug acquired with Encore Vision

pharmaphorum

The eyedrop formulation of UNR844 (lipoic acid/choline ester chloride) was acquired as part of the group’s buyout of privately-held ophthalmology biotech Encore Vision for $375 million upfront in 2017, and was designed to work by restoring the elasticity of the eye’s lens that declines with age.

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FDA suggests ways to curb constraints with rare disease gene therapy trials

Pharmaceutical Technology

Since the first approval in 2017, the FDA’s Office of Tissue and Advanced Therapies (OTAT) has approved 27 cell and gene therapies. One such example is Hemgenix (etranacogene dezaparvovec), the first gene therapy to treat adults with haemophilia B, which was approved in November.

FDA 105
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Advancing AOCs to transform the delivery of RNA therapeutics

European Pharmaceutical Review

Known linkers in the RNA field are used to bond together the two pharmacologically active molecular entities and can be applied to multiple oligonucleotide modalities. Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging. 2017; 376:86-88. Bennett CF, Krainer AR, Cleveland DW.

Safety 98
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Regenerative potential: cell?based therapies for heart failure

European Pharmaceutical Review

Pharmacological therapies mainly address symptoms and unfortunately a significant number of patients do not respond adequately, progressing to congestive heart failure and eventually needing a heart transplant. Frontiers in Pharmacology. Nature Publishing Group; 2017 [Cited 2023Mar]. 1 Furthermore, there are 63.3 BMC Cancer.