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Tackling the complex development landscape of pain medicines

European Pharmaceutical Review

The current medications (opioid and non-opioid) often force the patients to make an unfortunate choice between efficacy and debilitating side effects, leading to a cycling through multiple different therapies and suboptimal treatment response. 2017; 6(S1):1–3. Neuropathic pain: The scope of the problem. Pain and Therapy. Internet] NIH.

Medicine 102
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NICE to update endometriosis guidelines to improve diagnosis and surgical management

Pharmaceutical Technology

This marks the first update to NICE’s endometriosis guidelines since 2017, representing a huge milestone for patients and practitioners alike. This delay in diagnosis ultimately leads to disease progression and associated complications, such as chronic pelvic pain and infertility, which greatly affects the patients’ quality of life.

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Early diagnosis in Alzheimer’s disease: A first step towards better care

Clarivate

The pathophysiology of Alzheimer’s is complex and involves multiple mechanisms, including extracellular deposition of amyloid-β (Aβ) plaques and intracellular formation of neurofibrillary tangles (NFT) of tau, causing progressive neuronal loss and atrophy (Counts, 2017). Abbreviations: AD, Alzheimer’s disease; MCI, mild cognitive impairment.

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Regenerative potential: cell?based therapies for heart failure

European Pharmaceutical Review

Cardiovascular diseases are the leading cause of death globally with over 18.5 Cardiovascular diseases are the leading cause of death globally with over 18.5 Meta‑analyses of these trials have shown that the therapy is safe and can lead to a reduction in incidences of death and recurrent myocardial infarction. to 1 percent).

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FDA suggests ways to curb constraints with rare disease gene therapy trials

Pharmaceutical Technology

Blank acknowledged that in many cases, an exclusively paediatric patient population could lead to difficulties with drawing consent for early phase trials. Since the first approval in 2017, the FDA’s Office of Tissue and Advanced Therapies (OTAT) has approved 27 cell and gene therapies.

FDA 105
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Recurrent drug shortages signal onerous outlook for cardiovascular care

Pharmaceutical Technology

This is due to aging populations around the world, which leads to an increased risk of such conditions, explains Craig Beavers, PhD, assistant professor at the University of Kentucky’s College of Pharmacy in Lexington. Also, substitution can lead to further shortages, he adds.

Medicine 111
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Understanding a rare disease through the lens of real world and prevalence data

Clarivate

Degeneration of the retinal ganglion cells causes rapidly progressing vision loss, leading to permanent (non-painful) blindness within a year. 9; 9/2017; p447; DOI:10.1016/j.je.2017.02.001 9; 9/2017; p447; DOI:10.1016/j.je.2017.02.001 Frontiers in Pharmacology; 13:1089033; DOI: 10.3389/fphar.2022.1089033