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Early diagnosis in Alzheimer’s disease: A first step towards better care

Clarivate

The pathophysiology of Alzheimer’s is complex and involves multiple mechanisms, including extracellular deposition of amyloid-β (Aβ) plaques and intracellular formation of neurofibrillary tangles (NFT) of tau, causing progressive neuronal loss and atrophy (Counts, 2017). Abbreviations: AD, Alzheimer’s disease; MCI, mild cognitive impairment.

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Understanding a rare disease through the lens of real world and prevalence data

Clarivate

Using real world data to analyze LHON dynamics To better understand the dynamics of LHON, including disease prevalence and drug usage in the United States, we analyzed real world data from electronic health records (EHR), claims and pharmacy data from healthcare institutions and providers. 9; 9/2017; p447; DOI:10.1016/j.je.2017.02.001

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Recurrent drug shortages signal onerous outlook for cardiovascular care

Pharmaceutical Technology

According to some estimates, between 2017 and 2047, the number of individuals living with stroke will increase by 27% in the EU. As a result, healthcare providers need to rely on generic manufacturers, but there are only a few who make them, he explains. Here, the long-term shortages can be attributed to two factors, says Page.

Medicine 111
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Botanical drugs – what is the best way forward for regulatory and market approval?

European Pharmaceutical Review

2 Approach taken by regulators in the UK The Medicines and Healthcare products Regulatory Agency regulates herbal medicines in the UK. 20 Good manufacturing practice (GMP) Commission Directive (EU) 2017/1572 (which supplemented Directive 2001/83/EC) lays out the principles and guidelines of GMP in the EU. cited 2024May].

Marketing 103
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Developing new treatment regimens for HIV

European Pharmaceutical Review

About the author Sherene Min, MD, MPH, is Vice President of Global Clinical Development at ViiV Healthcare , a role she assumed in October 2019. With therapeutic expertise in HIV, hepatology and rare diseases, Sherene has additional expertise in clinical pharmacology and drug safety. Internet] 2017. Lancet HIV.

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Beyond animal testing: the rise of organs-on-chips technology

Clarivate

They became integral to physiological and pharmacological research during the 19th century and started to be systematically used for drug development during the 20th century. Clinical Pharmacology and Therapeutics, 104(6), pp. Animal experiments date back to ancient Egyptian and Greek civilizations. Barrile, R., Passini, E.,

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Why aren’t digital pills taking off?

Pharmaceutical Technology

In 2017, the US Food and Drug Administration (FDA) broke ground by approving the first drug with an embedded biosensor to track its use. There’s no dearth of interest, however, in applying digital solutions to healthcare. It potentially helps individuals lend some kind of concrete evidence to discussions with their healthcare provider.